The Monday-night series is scheduled to feature performances by Lauren Elder, Maya Sharpe, Allison Case and Brett Teresa.
Tiffany Schleigh and Julie Rebecca Holmes host the performance, which will be followed by an open mic session.
A portion of the beverage and food proceeds will go to St. Jude's.
There is no cover charge and no minimum. Rachel's is located on West 43rd Street and Ninth Avenue.