Part of The New York Comedy Festival, the 6 PM benefit production will help support the Scleroderma Research Foundation. Susie Essman, Jimmy Fallon, Gilbert Gottfried, Robin Williams will all perform in the evening at Carolines on Broadway.

Joining Saget as co-host will be SRF board member Caryn Zucker and her husband, NBC Universal President Jeff Zucker. Celebrity chefs will include Susan Feniger and Mary Sue Milliken of The Food Network's "Too Hot Tamales."

Saget appeared Off-Broadway in Paul Weitz's play Privilege in 2005. The host of NBC's game show "1 vs. 100" is also known for his previous television work on "Full House" and "America's Funniest Home Videos."

The Scleroderma Research Foundation helps fund medical research to find a cure for scleroderma. The SRF was founded in San Francisco in 1987 by scleroderma patient Sharon Monsky, who lost her battle to the disease in May 2002. For more information visit srfcure.org.

Tickets (starting at $500) for "Cool Comedy - Hot Cuisine" at Carolines on Broadway, 1626 Broadway, are available by calling (800) 441-CURE or visit sclerodermaRESEARCH.org.