The co-production begins at the Off-Broadway house Nov. 11 and opens Dec. 1. It will play the Princeton, New Jersey , theatre from Sept. 9 to Oct. 16.
Nielsen also starred in the world premiere of Durang's Mrs. Bob Cratchit’s Wild Christmas Binge at Pittsburgh's City Theatre in fall 2002.
Also in the cast are Lynda Gravátt, Mahira Kakkar, Jeremy Shamos and Colleen Werthmann.
The production features scenic design by David Korins, costume design by Jess Goldstein, lighting design by Jeff Croiter and sound design by Darron L. West.
Emily Mann of the McCarter Theatre will direct the New York premiere of Miss Witherspoon. "In life, Veronica was a lapsed Catholic — so why is she spending eternity in Purgatory with a Hindu spirit guide who calls her Miss Witherspoon? And why is she continually being sent back to earth to live lives she doesn't particularly want to lead? Will she open herself up to enlightenment and learn her place in the world? God only knows — or someone like God, anyway," according to PH notes. "Miss Witherspoon is a quirky black comedy about reincarnation, altering the course of world events…and Rex Harrison." Durang's plays at Playwrights Horizons include Sister Mary Ignatius Explains It All For You, The Actor's Nightmare, Baby with th+e Bathwater, Laughing Wild and Betty's Summer Vacation . His other plays on and Off-Broadway include A History of the American Film (Tony nomination), Beyond Therapy, Baby with the Bathwater, The Marriage of Bette and Boo, Durang/Durang and Sex and Longing.