A spokesperson for the Tony Award-winning revival, which is currently playing Lincoln Center Theater's Vivian Beaumont, told Playbill.com that O'Hara will play her final performance March 8.
As previously reported, O'Hara and husband Greg Naughton are expecting their first child. The couple wed in 2007.
O'Hara previously said that she hoped to return to the production later in the year. Neither a return date nor a replacement for O'Hara has been announced.
Kelli O'Hara earned her third Tony nomination for portraying Ensign Nellie Forbush in the Lincoln Center Theater revival of South Pacific. She was also honored with Tony nominations for her work in the Tony-winning revival of The Pajama Game and the Tony-winning musical The Light in the Piazza. On Broadway she has appeared in Jekyll & Hyde, Follies, Sweet Smell of Success and Dracula, the Musical. Her album, "Wonder in the World," is currently available on the Ghostlight Records label.
O'Hara will also make her Cafe Carlyle debut in March; the singing actress will play the posh venue March 31-April 11.
For further information about South Pacific, visit LCT.org.