Miranda will take audience questions and then will be joined by other Hamilton cast members to sign the original Broadway cast recording. The event begins at 3:30 PM.
The original cast recording of the new musical also arrives Oct. 16.
Barnes & Noble is located at 150 East 86th Street.
The new musical by Tony Award-winning In the Heights star and creator Miranda explores the life of American Founding Father Alexander Hamilton. Inspired by the book "Alexander Hamilton" by Ron Chernow, the musical incorporates historical figures such as George Washington, Aaron Burr, James Madison and Thomas Jefferson.
Hamilton plays the Richard Rodgers Theatre.