In the 1930s Hambourg toured Britian with such singers such as Paul Robeson, Lawrence Tibett, and Richard Tauber. She performed at the BBC Proms in 1938, and in Myra Hess's wartime concerts at the National Gallery.
After World War II, she gave up performing to focus on teaching and counseling music students, eventually establishing the Hope Hambourg Musical Trust, which gives grants to gifted children suffering economic hardship.
Hambourg returned to performing in the last few years before her death, recording Liszt's Legende No. 1 ("St. Francoise d'Assise: La Predication aux oiseaux") and Schumann's Phantasie in C, Op. 17, for Arbiter Records.