The daily, one-hour show — which tapes in Los Angeles, CA — will play in the New York area on WNBC at 3 PM. The host has already revealed Will Ferrell ("The Producers") will be her first guest.

"'The Megan Mullally Show' will be an entertaining hour featuring a mix of celebrities, real people, music and comedy," according to an NBC release. "Megan will interview top celebrities and also introduce the world to guests of all kinds-from quirky characters to funny kids to off-beat experts."

Best known for her role as Karen on the NBC series "Will & Grace," Mullally is remembered by theatregoers as Rosemary Pilkington in the 1995 revival of How To Succeed in Business Without Really Trying opposite Matthew Broderick. Her other stage creds include Marty in the 1994 revival of Grease. She has also performed her one woman musical, Sweetheart and numerous concert gigs at Lincoln Center, Kennedy Center, Chicago’s Goodman Theater and elsewhere.

The actress has previously hosted "Saturday Night Live" and subbed for David Letterman on CBS' "The Late Show."

Corin Nelson, Emmy Award-winning veteran daytime producer and former showrunner on "The Rosie O'Donnell Show," serves as Executive Producer. Mullally's band leader will be Brett Simmons. Ken Fuchs serves as director. For more information and to preview promotional videos, visit wnbc.com/meganmullally or your local NBC affiliate.