The awards ceremony, held at the Hammerstein Ballroom, will air on Comedy Central, Spike TV, TV Land, VH1, CMT, Logo and Nick At Nite April 10.
Other winners included actors Tina Fey and Zach Galifianakis for Best Comedy Actress and Actor in Film, Kristen Wiig for Best Comedy Actress in Television, "The Daily Show with Jon Stewart" for Best Late-Night Comedy Series, "Toy Story 3" for Animated Comedy Film and "The Other Guys" for Best Comedy Film.
Eddie Murphy accepted the Career Icon Award, and the Johnny Carson Award for Comedic Excellence was presented to David Letterman.