Krasinski and Rudolph appear as young expecting parents who journey across America in search of a place to call "home" for their new family. Tony and Academy Award nominee Toni Collette and Cheryl Hines ("Curb Your Enthusiasm") have been previously confirmed to appear in the film as well.

Newly added to the project are screen veterans Jeff Daniels, Allison Janney and Catherine O'Hara as well as Carmen Ejogo, Jim Gaffigan, Melanie Lynskey, Chris Messina, Kevin J. O’Connor and Paul Schneider.

As previously reported, "A Heartbreaking Work of Staggering Genius" author Dave Eggers and his wife Vendela Vida, a novelist and editor of "The Believer" magazine, have penned the original screenplay. Ed Saxon, Marc Turtletaub, Peter Saraf of Big Beach Films, and Mendes' Neat Street Productions will produce the film, tentatively titled "This Must Be the Place."

Filming is set to begin in Connecticut this week, with additional locations in Arizona and Florida.

Sam Mendes made his Broadway directorial debut with the critically acclaimed revival of Cabaret, which earned the 1998 Tony for Best Revival of a Musical. As artistic director of the Donmar Warehouse, Mendes earned Tony Awards for presenting the Broadway productions of Take Me Out and The Real Thing. He staged the 2003 revival of Gypsy starring Bernadette Peters. For his directorial film debut, Mendes received the Academy Award for Best Director on "American Beauty."