The tenor will be honored with a lifetime achievement award at the ceremony, which will be hosted by British talk show host Michael Parkinson.
BPI Chairman Peter Jamieson said, "We are delighted that the great Plšcido Domingo, an artist who excels not just as tenor but as conductor, will be joining us. It promises to be a truly extraordinary event."
The Classical Brit Awards has taken place at the Royal Albert Hall each May since it was founded by the BPI in 2000 as an offshoot of the Brit Awards for pop music. The event combines live performances with awards in various categories. Nominations for the 2006 awards will be announced in April.
Winners in 2005 included Marin Alsop as female artist of the year and Bryn Terfel as male artist of the year. John Williams won the soundtrack composer award, and John Adams' On the Transmigration of Souls won the contemporary music award.
Domingo will be in London in May to sing six performances at the Royal Opera House in the lead role of Franco Alfano's Cyrano de Bergerac.