Barton, who is best known for playing Honey Mitchell in the BBC TV series "EastEnders", has previously appeared onstage as Peggy in The Secret Garden for the RSC and Marty in Grease at the Victoria Palace. Other TV includes BBC1's "Spooks".
She will be joined by Vivien Carter as Velma. Carter's credits include We Will Rock You in Australia and Guys and Dolls in the West End, with Terence Maynard as Billy Flynn and Adam Stafford as Amos Hart.
To book tickets, contact the box office on 0844 412 4652, or visit www.chicagothemusical.co.uk for more details.