Fox's hit musical-themed series will start off its second season Sept. 21 at 8 PM ET. As previously reported, the Emmy-nominated series will air in the same Tuesday-night slot until mid-season, when it will switch to Tuesdays at 9 PM starting with a post-Super Bowl episode in February 2011.

The fall season premiere of "Glee" will be followed by the family comedy "Raising Hope," which features Tony nominee Martha Plimpton and stage and screen veteran Cloris Leachman in its cast (at 9 PM ET), and by "Running Wild," a romantic comedy featuring Will Arnett and Keri Russell (at 9:30 PM ET).

Matthew Morrison (South Pacific, The Light in the Piazza) stars as Spanish teacher Will Schuester with Spring Awakening's Lea Michele as glee club Broadway baby Rachel Berry with fellow glee club members Jenna Ushkowitz as Tina, Chris Colfer as Kurt, Kevin McHale as Artie, Cory Monteith as Finn Hudson and Amber Riley as Mercedes Jones.

The ensemble cast also includes Jane Lynch as cheerleading coach Sue Sylvester, Jessalyn Gilsig as Terri Schuester, Jayma Mays as teacher Emma Pillsbury, Dianna Agron as cheerleader Quinn and Mark Salling as football player Puck.

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