David Esbjornson (who staged Albee's Tony Award-winning The Goat, or Who Is Sylvia?) directs the production, to play to March 25 as the inaugural production in The End Stage Theatre at the resident company's new Frank Gehry-designed Pershing Square Signature Center at 480 W. 42nd Street between Dyer and 10th Avenues. The official opening night is March 5.

Alexander is joined by Catherine Curtin (Love, Janis), Michael Hayden (Carousel, Festen, Cabaret), Peter Francis James (The Merchant of Venice), Tricia Paoluccio (A Strange and Separate People), Laila Robins (Frozen), Thomas Jay Ryan (In the Next Room or the vibrator play) and C.J. Wilson (Festen, Henry IV).

Here's how Signature characterizes the play by the author of Who's Afraid of Virginia Woolf?: "At a late-night party, Sam and Jo entertain their friends with a round of Twenty Questions and another round of drinks. When an unexpected guest and her mysterious companion arrive, the question 'Who are you?' gains a whole new and desperate meaning."

Albee was one of Signature's past resident writers, in 1993-94. The return of an Albee title this season is part of Signature's Legacy Program.

The Lady From Dubuque design team includes John Arnone (scenic design), Elizabeth Hope Clancy (costume design), David Lander (lighting design), John Gromada (sound design) and Rick Sordelet (fight direction). The production stage manager is David H. Lurie and the stage manager is Andrew C. Gottlieb. Casting is by Telsey + Company.

Single tickets are now on sale. For information, call (212) 244-7529 or visit www.signaturetheatre.org.