Directed by Michael Kimmel, the limited engagement will continue through Feb. 4.
The cast comprises Kim Blair, Maggie Bofill, Amirh Vann Rosario and Jeffrey Withers.
"Humans never adapt as quickly as the viruses they battle in...[this new play] about four cohabiting epidemiologists in a race against time," according to press notes. "Science gets personal as they fight to contain a potentially devastating outbreak, while trying to keep their relationships from unraveling. Instinct ultimately reveals that nothing is more contagious than human desire."
The production also features set and lighting design by Ben Kato, costume design by Christina Bullard, sound design by Andrew Ingkavet and video design by Aaron Rhyne.
An earlier incarnation of Instinct, called Wax Wings, premiered in spring 2011 at New York's Wild Project, a special commission by Emory University, as part of their Science of Evolution Conference in 2008. Maguire attended the conference and was asked to write a play based on topics discussed. He worked closely with molecular epidemiologist Dr. Leslie Real through the process; Real is credited with successfully saving African Great Apes who were in danger of being wiped out by the Ebola virus.
Maguire's plays include The Seven Deadly Elements, based on the collage novel by Max Ernst, Eye Figure Fiction, Untitled (The Dark Ages Flat Out), The American Mysteries, The Memory Theatre of Giulio Camillo, Propaganda, Fun City, Visions of Don Juan, The Tower, and its solo version, Babel Stories.
Theatre Row's Lion Theatre is located at 410 West 42nd Street. Tickets are $18 and are available at www.telecharge.com or via telephone at (212) 239-6200.