The performance will be the Pops' first at the annual event, which draws more than three million spectators and is broadcast nationally on NBC starting at 9 p.m. ET (check local listings).
"I've always gazed in awe at the Macy's celebrations of Independence Day and Thanksgiving," Henderson said. "Lo and behold, this year we finally ascend their platform."
The musical program includes patriotic songs and an excerpt from Gershwin's Rhapsody in Blue.