Daniella Topol will direct the work, which runs through April 4 in the Cherry Lane Studio.
The cast includes Saxon Palmer (The Glass Cage), Evan Thompson (Stretch (A Fantasia)) and Monique Vukovic (God's Ear).
Housebreaking, according to press notes, is "about a 35-year-old man bored with his job and his life, and what happens in his own family of misfits when he brings a man living on the streets into their home, thus considering the cunning it takes to survive on the streets, or in your own home."
Housbreaking has scenic design by Mimi Lien and Amy Rubin, costume design by Theresa Squire and lighting design by Nicole Pearce.
Holder's plays also include Bedtime Solos, The Shoulder, Darktime in Skipland, Not An Island, Sumatra Mandheling and American Beacon, and the Spirit of Christmas Past. For tickets phone (212) 239-6200 or visit Telecharge.com. The Cherry Lane Theatre is located in Manhattan at 38 Commerce Street, between Barrow and Bedford Streets.
Further information is available by visiting CherryLaneTheatre.