Page, who created the roles of Norman Osborn/Green Goblin, will next be seen in the Roundabout Theatre Company's production of Cyrano de Bergerac in the role of Comte de Guiche.
Page will be succeeded in Spider-Man by Robert Cuccioli, best known for his Tony Award-nominated turn in the dual title roles of Jekyll and Hyde, who begins performances Aug. 7 at the Foxwoods Theatre.
"There aren't a lot of actors out there who can pull off utterly likable and totally terrifying at the same time, and so we feel extremely lucky that the great Robert Cuccioli has agreed to take on this role," said producers Michael Cohl and Jeremiah J. Harris in a previous statement.
"Of course, this announcement is bittersweet for all of us, because throughout the extraordinary history of Spider-Man: Turn Off The Dark, Patrick Page has been there every step of the way — as a mentor, cheerleader, spokesperson, company leader and consummate performer," added Cohl and Harris. "We are, of course, sorry to see him go, but will all be cheering him on in Cyrano."