The show won the 2008 Tony Award for Best Musical.
Cooked up by actor-writer Lin-Manuel Miranda when he was a student at Wesleyan University in Connecticut, the show opened on Broadway March 9, 2008.
Miranda, who won the Tony for Best Score for the show, was also nominated as Best Actor in a Musical. He rejoined the cast on Dec. 25 for the final two weeks of the run.
Here is a look at the closing night:
PHOTO RECAP: Looking Back at In the Heights' Broadway Closing Night
Miranda's kinetic Usnavi is a Dominican bodega owner who guides us through a couple of days in the life of friends, family and lovers in the Latino-populated northern Manhattan neighborhood of Washington Heights.
The final cast featured Arielle Jacobs, Andréa Burns, Marcy Harriell, Priscilla Lopez, Olga Merediz, Rick Négron, Courtney Reed, Christoper Jackson and Seth Stewart with Sharona D'Ornellas, Rosie Lani Fiedelman, Rubén Flores, Marcus Paul James, Jennifer Locke, Doreen Montalvo, Noah Rivera, Eliseo Román, Gabrielle Ruiz, Marcos Santana, Rickey Tripp, Willis White, Michael Balderrama, Blanca Camacho, Allison Thomas Lee, Alejandra Reyes, Alicia Taylor Tomasko and Daniel J. Watts.