The play will begin previews on Oct. 4 at the Brooks Atkinson.
Garrett told of his casting in a May 11 interview with the Chicago paper. "I am so excited about this," he said. "They're even talking of having me understudy Nathan. Hmmm. Now I just have to figure out how to poison him."
For nine seasons, Garrett play Robert, the policeman brother of Ray Romano of the popular sitcom.
Reheasals are to begin on Sept. 6. Emanuel Azenberg, Ira Pittelman, Jeffrey Sine, Max Cooper and Ben Sprecher are producing.
Joe Mantello will direct the staging, which would reunite the stars of The Producers. The venture would likely be a limited run. Broderick recently performed Off-Broadway in The Foreigner. Lane, meanwhile, reprised his role of Max Bialystock in the London premiere of The Producers.
Lane and Broderick will play Oscar Madison and Felix Unger in Simon's classic The Odd Couple. Lane would be the sloppy sportswriter Madison, while Broderick would be the uptight photographer Felix Unger.
In addition to his Tony-winning roles in The Producers and A Funny Thing Happened on the Way to the Forum, Nathan Lane has starred on The Great White Way in Present Laughter, Merlin, The Wind in the Willows, Some Americans Abroad, On Borrowed Time, Guys and Dolls, Laughter on the 23rd Floor, Love! Valour! Compassion! and The Man Who Came to Dinner.
Matthew Broderick received Tony Awards for his performances in Brighton Beach Memoirs and the revival of How to Succeed in Business Without Really Trying. He was also Tony-nominated for his work in The Producers, and his other theatre credits include Biloxi Blues, Night Must Fall, Taller Than a Dwarf, On Valentine's Day, Torch Song Trilogy and The Widow Claire.
The original Broadway production of The Odd Couple opened at Broadway's Plymouth Theatre in March 1965. Art Carney and Walter Matthau starred as, respectively, Felix and Oscar. The production won four 1965 Tonys, including awards for Matthau (Actor), Simon (Author), Mike Nichols (Director) and Oliver Smith (Scenic Designer). Matthau then repeated his role on film opposite the Felix of Jack Lemmon. The long-running TV version of Simon's work featured Jack Klugman (Oscar) and Tony Randall (Felix).