The actress-comedian is among a roster of comedy stars taking part in the week-long festival presented at the city's top venues.
Joining O'Donnell at Avery Fisher Hall will be "a number of special guests," according to an announcement for the 8 PM performance. Proceeds will benefit Rosie's Broadway Kids.
Current The Drowsy Chaperone star Bob Saget will host the "Cool Comedy - Hot Cuisine" benefit Nov. 6 at Carolines, as part of the festival. The line-up of stars at that 6 PM show (supporting the Scleroderma Research Foundation) include Susie Essman, Jimmy Fallon, Gilbert Gottfried and Robin Williams.
Stage and screen star Mario Cantone (Assassins, Laugh Whore, "Sex and the City") will lend his talents to the festivities as well. He performs Nov. 8 and 11 (at 7:30 PM) at Carolines.
The fourth annual event also includes such comic acts as Sarah Silverman (Carnegie Hall - Nov. 7), Denis Leary (Beacon Theatre - Nov. 8), Louis CK (Town Hall - Nov. 8), Artie Lange (Town Hall - Nov. 9 and 11), Damon Wayans (Beacon Theatre - Nov. 9), Bill Maher (Beacon Theatre - Nov. 10) and D.L. Hughley (Town Hall - Nov. 10). As producer (Taboo), star (Fiddler on the Roof, Seussical) and all around Broadway cheerleader, O'Donnell has been a prominent player in the theatre community. The actress — seen in the films "A League of Their Own," "Sleepless in Seattle," "Now and Then," "Beautiful Girls" and heard (in voice) on "Tarzan" — has also been seen on the small screen. In addition to her hosting work on "The Rosie O'Donnell Show" and "The View, she has put in memorable turns on "Nip/Tuck," "Queer as Folk," "Will & Grace," "The Practice," "Ally McBeal" and more.
For tickets and more information on the 2007 NYCF, visit nycomedyfestival.com.