Initially, McLean's style was similar to Parker's; in the 1960s, he embraced the "free jazz" of Ornette Coleman.
In 1970, McLean began teaching at the Hartt School of music at the University of Hartford. He eventually founded the African-American Music program there, one of the first degree programs dedicated to jazz, according to the Times. It is now known as the Jackie McLean Institute of Jazz.
He received the NEA Jazz Master award, the nation's highest honor for jazz musicians, in 2001.