The annual celebration of film will be broadcast live Feb. 24, 2013, on the ABC Television Network.
"We are thrilled to have Seth MacFarlane host the Oscars. His performing skills blend perfectly with our ideas for making the show entertaining and fresh," said Zadan and Meron in a joint statement. "He will be the consummate host, and we are so happy to be working with him."
"It's truly an overwhelming privilege to be asked to host the Oscars," added MacFarlane. "My thoughts upon hearing the news were, one, I will do my utmost to live up to the high standards set forth by my predecessors; and two, I hope they don't find out I hosted the Charlie Sheen Roast."
"Seth is unbelievably talented," said Academy president Hawk Koch. "We couldn't be happier with the creative team we've assembled. With Craig, Neil, and now Seth, we're off to a great start."
MacFarlane made his feature directorial debut this summer with the box-office success "Ted. He also co-wrote and produced the film, and voiced the title character. MacFarlane is the creative force behind the television series "Family Guy" and co-creator of "American Dad!" and "The Cleveland Show. In September he hosted "Saturday Night Live" for the first time, for the show's 38th season premiere. An accomplished live performer, MacFarlane has played to sold-out audiences at London's Royal Albert Hall and New York's Carnegie Hall. In 2011 he released his debut album, "Music Is Better Than Words," which earned two Grammy nominations. He also has earned 13 Emmy nominations and won two for his work on "Family Guy."