Fraser, whose West End credits include the musicals Les Miserables and The Far Pavilions, created the role of Tiernan in the world premiere of The Pirate Queen opposite Block in the title role, at Broadway's Hilton Theatre in 2007.
Block, who was last seen on Broadway as Judy Bernly in the musical 9 to 5, has also appeared in The Boy from Oz (playing Liza Minnelli) and Wicked. Her performance in the national tour of the Stephen Schwartz musical earned her a Helen Hayes Award.
They are joined by the previously-announced Annalene Beechey and Oliver Tompsett, both alumni of the London production of Wicked.
They will be backed by a four-piece band under the musical direction of Dominick Amendum. Block will offer hightlights from her solo debut recording "This Place I Know" and take audiences through her numerous stage roles.
To book tickets, contact the box office on 020 7478 0135, or visit www.newplayerstheatre.com