Previews under the direction of Joe Mantello begin April 9 toward an April 29 opening. This is a limited engagement through June 20.

The rueful comedy about middle-aged relationship ruminations at a Fire Island beach house will have a design team that includes John Lee Beatty (sets), Tom Broecker (costumes), Paul Gallo (lights) and Darron L West (sound).

According to Roundabout, "Lips Together, Teeth Apart takes place on the elegant deck of a beach house on Fire Island. A brother and sister and their respective spouses attempt to celebrate the Fourth of July with a gnawing uncertainty that makes their affluent habits and petty prejudices sizzle in the summer sun. In this unforgettable comedy, Terrence McNally does for the beach house what Chekhov did for the Russian country estate."

Mullally ("Will & Grace," Young Frankenstein, How to Succeed…) plays Chloe Haddock; Oswalt (Remy in "Ratatouille") plays Sam Truman; Taylor (Obie and Drama League winner for Aunt Dan and Lemon, Emmy nominee for "Six Feet Under") plays Sally Truman; and Barnes plays John Haddock.

McNally and Mantello most recently collaborated at Roundabout Theatre Company on the comedy The Ritz at Studio 54. Mantello, an associate artist at Roundabout Theatre Company, received a Tony Award for staging the 2004 Tony winning production of Assassins. He also directed Noël Coward's Design for Living and Rodgers & Hart's Pal Joey. Beginning Feb. 15, tickets will be available exclusively to American Express Cardmembers at www.roundabouttheatre.org, by phone at (212) 719-1300, or at the American Airlines Box Office (227 West 42nd Street).

The public on-sale begins Feb. 23 by calling Roundabout Ticket Services at (212)719-1300, online at www.roundabouttheatre.org or at the American Airlines Box Office.

Lips Together, Teeth Apart will play Tuesday through Saturday evening at 8 PM with Wednesday, Saturday and Sunday matinees at 2 PM.

For more information, visit www.roundabouttheatre.org.