Ryan Murphy ("Running with Scissors," "Nip/Tuck") will direct the drama he co-created with writer Brad Falchuk "about a man who realizes he's a transsexual," according to the trade magazine. Murphy executive produces with Brad Pitt and Dede Gardner.

The trade publication reports Fiennes will play the lead — a married man and father of two sons — who will eventually become a woman. Danner and Wagner will play his parents. Casting for the other roles is underway for the production to begin late October.

FX ordered the pilot episode of the new series — which previously went by the title "4 oz.," a reference to the average weight of a penis — and three additional scripts.

Fiennes is currently onstage in the West End in the title role of Epitaph for George Dillon. He has also been seen on stage in Trevor Nunn's Love's Labours Lost, Edward II, Troilus and A Month in the Country. His film roles include the title role in "Shakespeare in Love" as well as "Elizabeth," "Enemy at the Gates," "The Merchant of Venice" and "Running With Scissors."

Danner — last seen Off-Broadway in Tennessee Williams' Suddenly Last Summer — won two consecutive Emmy Awards for her turn on Showtime's "Huff." The actress won a Tony Award for her Broadway debut in Butterflies Are Free and was further nominated for A Streetcar Named Desire, Betrayal and Follies. Other credits include Much Ado About Nothing, The Seagull, The Royal Family and movie roles in "1776," "The Great Santini," "Mr. & Mrs. Bridge," "Brighton Beach Memoirs," "Meet the Parents" and "Sylvia."