Shatner's World: We Just Live in It will play two or three weeks at the Music Box Theatre in February 2012. The Music Box is currently the home of the revival of Noel Coward's Private Lives, which is ending its run earlier than scheduled.
The Broadway engagement will kick off a 15-week national tour, according to the New York daily.
Shatner has previously appeared on Broadway in A Shot in the Dark, The World of Suzie Wong and Tamburlaine the Great.
No official announcement about Shatner's one-man show has been made.