The play, set to open July 16, will run at the downtown Manhattan venue through Aug. 24.

Flesh and Blood is based on the epic novel by Cunningham (Pulitzer Prize winning "The Hours") which spans over 100 years in the lives of three generations of an American family from their 1930 New York arrival.

Doug Hughes (Scattergood, Othello) directs the production. The design team includes Christine Jones (sets), Paul Tazewell (costumes), Scott Zielinski (lighting) and David Van Tieghem (sound) — who also provides original music.

The cast includes Jones, Plimpton, Patricia Buckley, Airrion Doss, Sean Dugan, Peter Frechette, Gaitens, Jessica Hecht, Chris McGarry, John Sierros and Jeff Weiss.

Actress Jones, who appeared in "Signs," recently played in the Broadway production of Imaginary Friends. Plimpton, known for roles in such films as "The Goonies," was last seen in David Mamet's Boston Marriage at the Public Theatre. Hecht, who played in The Last Night of Ballyhoo on Broadway, recently starred in The Fourth Sister. Frechette's recent credits include What the Butler Saw and The Dazzle. McGarry played in Salome on Broadway and appeared in Where's My Money? Weiss has played on Broadway in The Invention of Love, The Iceman Cometh and Ivanov.

For more information or tickets to NYTW shows, 79 East Fourth Street (between Bowery and Second Ave.), call (212) 460-5475. Also visit their website at www.nytw.org.