The actor will play an art gallery owner on the eighth episode of the show's final season.
Jordan, who was last seen in the Off-Broadway production of Lucky Guy, is best known for playing Beverley Leslie on "Will & Grace," for which he won an Emmy. He has also appeared Off-Broadway in his solo show My Trip Down the Pink Carpet.
"Desperate Housewives" airs Sunday nights at 9 PM ET on ABC.