It will be a family affair on West 49th Street when Griffith begins playing Roxie Hart July 11 at the Ambassador Theatre, directly across the street from the Eugene O’Neill Theatre, where husband Antonio Banderas is currently starring in Nine. Griffith will begin rehearsals this week for her Main Stem debut, and she is scheduled to stay with the award winning musical through Sept. 28. Among Griffith’s many screen credits are “Working Girl,” “The Bonfire of the Vanities,” “Paradise,” “Born Yesterday,” “Mulholland Falls,” “Lolita,” “Cecil B. DeMented” and “Stuart Little 2.” Griffith was nominated for an Academy Award for her performance in “Working Girl.”

Chicago won the Tony for Best Revival of a Musical in 1997 as well as awards for actors Bebe Neuwirth and James Naughton, director Walter Bobbie, lighting designer Ken Billington and choreographer Ann Reinking. The original production was directed and choreographed by the late Bob Fosse.

Chicago plays Monday, Tuesday, Thursday and Friday evenings at 8 PM, Saturdays at 2 and 8 PM and Sundays at 2 and 7 PM. (Beginning April 14, Chicago will play Tuesdays at 8 PM, Wednesdays at 2 and 8 PM, Thursday and Fridays at 8 PM, Saturdays at 2 and 8 PM and Sundays at 3 PM. Beginning April 27, Sunday performances will be held at 6:30 PM only.) The Ambassador Theatre is located at 215 West 49th Street. For ticket information, call Telecharge at (212) 239-6200 or visit www.telecharge.com.