The co-production with Second Stage Theatre will open May 6 at the New Haven, Connecticut company's New Theater. Connie Grappo directs the staging set to run through May 22. (The work will play in New York in July as part of the New Plays Uptown series.) The Mystery Plays follows the intertwined retellings of two separate mysterious tragedies: "a train wreck in the Northeast corridor and a desperate expedition to find meaning in an incomprehensible crime in Oregon," a release states. Both chance events shed light on the other.

Creel is joined in the cast by Scott Ferrara (Henry IV - Parts I and II, Lincoln Center), Leslie Lyles (Roulette), Mark Margolis (Christmas in Naples, Williamstown Festival), Heather Mazur (The Violet Hour) and Peter Stadlen (Birdy).

The design team for The Mystery Plays is Sandra Goldmark (scenic), Amanda Walker (costume), S. Ryan Schmidt (lighting) and Keith Townsend Obadike (sound). Scott French and Rachel Rusch serve as dramaturgs.

Grappo's directorial credits include Annie Weisman's Hold Please and Rob Ackerman's Tabletop (Working Theatre), Belmont Avenue Social Club, On House, Spread Eagle and Century City.

Aguirre-Sacasa is a Yale School of Drama graduate. His plays include Rough Magic, Golden Age, 2003 International Fringe Festival playwriting winner Say You Love Satan and The Muckle Man — which played as part of The Public Theater's 2002 New Work Now! Series.

Tickets to The Mystery Plays at Yale Rep's New Theatre, 1156 Chapel Street in New Haven, CT are available by calling (203) 432-1234 or visiting www.yalerep.org.